Also find us on Mendeley:

 

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition.

Hits: 461
Research areas:
  • Uncategorized
Year: 2015
Type of Publication: Article
Journal: Chemical communications (Cambridge, England) Volume: 51
Number: 46 Pages: 9499-502
ISSN: 1364-548X
BibTex:
Abstract:
In this study, we investigated the efficacy of an LNA (locked nucleic acid)-modified DNA aptamer named RNV66 targeting VEGF against various breast cancer cell lines. Our results demonstrate that RNV66 efficiently inhibits breast cancer cell proliferation both in vitro and in vivo. Introduction of LNA nucleotides were crucial for higher efficacy. Furthermore, the binding interaction of RNV66 with VEGF was investigated using molecular dynamic simulations leading to the first computational model of the LNA aptamer-VEGF complex blocking its interaction with VEGF-receptor.
Online version
 

sdulogo

Search

 
 
 
 

Joomla Templates by Joomla51.com